ADCs (Antibody Drug Conjugates) combine the best of two modalities, toxic efficacy and antibody specificity. The result is an improved therapeutic window with fewer side effects. However, the bioanalytical requirements for PK analysis also require a multifaceted approach. Here-in we describe various mass spectrometry based strategies Frontage has successfully applied in the bioanalysis of ADC’s for clinical and preclinical studies.
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ADC 2019

ADCs (Antibody Drug Conjugates) combine the best of two modalities, toxic efficacy and antibody specificity. The result is an improved therapeutic window with fewer side effects. However, the bioanalytical requirements for PK analysis also require a multifaceted approach. Here-in we describe various mass spectrometry based strategies Frontage has successfully applied in the bioanalysis of ADC’s for clinical and preclinical studies.

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